Fixing a Hole Where the Ras Gets In
نویسندگان
چکیده
A clinically efficacious Ras inhibitor has eluded drug-discovery efforts for decades. In a paper in Nature, Zimmermann and et al. show that blocking a hole in PDEδ that normally engages the lipid tail of Ras disrupts downstream signaling, pointing to a potentially promising route to develop Ras inhibitors for cancer treatment.
منابع مشابه
Evaluation of psychopharmacological and neurosafety profile of Swas Kas Chintamani Ras (SKC) in Swiss-Webster mice
Objectives: Swas Kas Chintamani Ras (SKC) is an ayurvedic preparation indicated for respiratory diseases. Our study was aimed to determine the psychopharmacological and neurosafety profile of SKC. Materials and Methods: Psychopharmacological effects and neurosafety profile of this drug were determined by nine complementary test methods namely, open field, locomotor activity, hole cross, hole bo...
متن کاملThe Proposed Method of using Plaster Nails for Fixing the Jouq Garden Monument Ceiling Painting Ornaments (Morteza Gholi Khan Egbalosaltaneh Palace, Sardar Maku)
The method of using plaster nails for fixing the mansion of Morteza Gholi Khan Egbalosaltaneh, the commander of Maku, in Qajar period was purposed. These paintings are important for art researchers since it is the beginning of a kind of innovation in Iranian art in Gajar period (Fig.1). The western elements have been used in the interior design of the mansion and the execution of interior decor...
متن کاملOn Marginal Automorphisms of a Group Fixing the Certain Subgroup
Let W be a variety of groups defined by a set W of laws and G be a finite p-group in W. The automorphism α of a group G is said to bea marginal automorphism (with respect to W), if for all x ∈ G, x−1α(x) ∈ W∗(G), where W∗(G) is the marginal subgroup of G. Let M,N be two normalsubgroups of G. By AutM(G), we mean the subgroup of Aut(G) consistingof all automorphisms which centralize G/M. AutN(G) ...
متن کاملCold work simulation of hole expansion process and its effect on crack closure
Using cold working fastener holes is a simple life enhancement procedure that strengthens metallic components by retarding crack growth around a hole. In the present paper, the residual stress field that is induced by the hole expansion process is obtained based on different material models namely elastic perfect plastic, isotropic hardening and kinematic hardening using three-dimensional finit...
متن کاملThe Relationship between Rhetorical moves and Lexical Cohesion Patterns; the case of Introduction and Discussion sections of Local and International Research Articles
Communicative moves and lexical cohesion patterns (LCPs), as mounting evidence shows, are two important indicators in writing and publishing the RAs. However, the interaction between these two crucial elements and the contribution of this interaction to the failure or success of the RAs have not been given due attention to date. Having this in mind and based on a sound theoretical framework, at...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cell
دوره 153 شماره
صفحات -
تاریخ انتشار 2013